Disseminated Bacillus Calmette-Guérin Disease after BCG Vaccination: A Case Report from China

Authors

  • Kun Chen Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health
  • Lin Zheng Institute of Immunization and Prevention, Xihu District Center for Disease Control and Prevention, Hangzhou, China
  • Luoya Ling Institute of Immunization and Prevention, Zhejiang Center for Disease Control and Prevention
  • Mingjuan Jin Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health
  • Shuyun Xie Institute of Immunization and Prevention, Zhejiang Center for Disease Control and Prevention
  • Xiaohua Qi Institute of Immunization and Prevention, Zhejiang Center for Disease Control and Prevention
  • Ye Ding Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health
  • Youqing Wang Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health
Abstract:

Background: Bacillus Calmette-Guérin (BCG) vaccination is recommended for newborn infants worldwide to prevent tuberculosis. However, complications do occur inevitably in a very low rate, among which the most serious is disseminated disease. The disseminated bacillus Calmette–Guérin disease is a rare disease with high fatality, and can be seen among persons with an underlying immunodeficiency. Case presentation: We report a 4-month-old male infant presenting with recurrent fever, an isolated left axillary massand swelling at the site of BCG inoculation. The cellular immune function analysis showed that the value of CD4/CD8 was 0.994, indicating the existence of immunodeficiency.The results of blood culture and throat swab culture showed conditional pathogen infection. He died of cardiopulmonary failure. Conclusion: In this case, necropsy played a significant role in the final diagnosis of disseminated pulmonary tuberculosis.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

disseminated bacillus calmette-guérin disease after bcg vaccination: a case report from china

background: bacillus calmette-guérin (bcg) vaccination is recommended for newborn infants worldwide to prevent tuberculosis. however, complications do occur inevitably in a very low rate, among which the most serious is disseminated disease. the disseminated bacillus calmette–guérin disease is a rare disease with high fatality, and can be seen among persons with an underlying immunodeficiency. ...

full text

Disseminated Bacillus Calmette-Guérin Disease after BCG Vaccination: A Case Report from China.

Background: Bacillus Calmette-Guérin (BCG) vaccination is recommended for newborn infants worldwide to prevent tuberculosis. However, complications do occur inevitably in a very low rate, among which the most serious is disseminated disease. The disseminated bacillus Calmette–Guérin disease is a rare disease with high fatality, and can be seen among persons with an underlying immunodeficiency. ...

full text

"presumed systemic bacille calmette-guérin disease after bcg vaccination: report of a clinical case "

bcg (bacille calmette–guérin) vaccine is administered worldwide to prevent severe forms of tuberculosis. it is considered to be safe; however, occasional complications are seen. the most serious complication is bcgosis. we report a case of bcgosis with granulomatous hepatitis and acid-fast bacilli in liver and spleen. we treated the patient with antituberculosis drugs without any response to tr...

full text

Sternal Osteomyelitis after Bacillus Calmette-Guérin Vaccination

Presented here is the case of a nine-month-old boy with the osteomyelitis of the upper area sternum caused by bacillus Calmette-Guerin (BCG), the Danish 1331 strain vaccine against tuberculosis. Upon examination, a swelling of approximately 2×3 cm diameter was observed in the upper sternal area. The mass was hard, fixed and sensitive to palpation with no local skin hyperaemia. Chest X-rays reve...

full text

Variability of Bcg Strains (bacillus Calmette-guérin)

Three different cultures of BCG propagated for over 2 years in a liquid medium containing Tween 80 and albumin were found to differ in several of their intrinsic properties. Cultures of the three strains were found to consist of morphologically heterogeneous populations-each culture being made up of three main colonial types-spreading, intermediate, and non-spreading. The percentage distributio...

full text

Disseminated Bacillus Calmette-Guérin Infection and Immunodeficiency

Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 5, May 2007 799 Jennifer Cuellar-Rodríguez,* Arturo Galindo-Fraga,* Víctor Guevara,* Carolina Pérez-Jiménez,* Luis Espinosa-Aguilar,* Ana Lilia Rolón,* Araceli Hernández-Cruz, * Esaú López-Jácome,* Miriam Bobadilla-del-Valle,* Areli Martínez-Gamboa,* Alfredo Ponce-de-León,* and José Sifuentes-Osornio* *Instituto Nacional de Ciencias ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 12  issue 1

pages  70- 73

publication date 2015-03-01

{@ msg @}

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023